More than ten class cancer-restraining gene older than is discovered so far, and, as for the cancer-restraining gene (Tumor suppressor gene), there are p53 (for mainly, large bowel cancer, breast cancer), Rb (a retina blastoma, the osteosarcoma face each other mainly), BRCAI (for mainly familial breast cancer, the uterine cancer), MSH2 (for the mainly gene-related large bowel cancer) as a cancer-restraining gene known in particular with a gene encoding protein (cancer restraint protein) with the ability to control the onset of the cancer.
It is a p53 gene to have been authorized as a cancer-restraining gene next to Rb, and a p53 gene is a gene exfoliated alone in 1979, and it was done with the one of the oncogenes since it was authorized in 1979, but it is p53 which it mutated for an oncogene, and it becomes clear that an original p53 gene is a gene restraining cancer.
The work of the p53 gene is introduced to many divergences, and check point control, an apoptotic instruction, the work of the transcription factor are known in a GI/S cell cycle; cross the function of each cancer restraint protein again in many divergences such as the transcription of check point control and the transcription factor, control, the restoration of the DNA in a cell cycle.
The both sides of two cancer-restraining genes do not have production of the cancer restraint protein by the damage with the cell of the double body and become.
